How is the incidence and severity of oral mucositis influenced by patient-related factors?

If a patient with a clinically significant comorbidity must continue taking a drug that alters CYP3A4-mediated metabolism, can he/she still be given ruxolitinib for newly diagnosed PMF?

Case Study 4: A Patient With Primary Myelofibrosis With Progressing Splenomegaly

Is ruxolitinib an appropriate therapy in patient with MF without significant splenomegaly?

Special Considerations for Younger Patients

How common is the JAK2 V617F mutation in essential thrombocythemia, and does it affect patient outcome?

How does chemotherapy induced oral mucositis represent a therapeutic challenge frequently encountered in cancer patients?

If a patient has erythrocytosis e.g. a Hgb in a male of >18.5 but on further evaluation the patient does not have PV or other MPN is there a benefit to therapeutic phlebotomy? If yes at what Hgb do you initiate it? What is your target in this situation?
Why do so many patients with polycythemia vera have pruritus?

Case Study 1: A Man Presents with Symptoms Consistent with an MPN

Are there certain subsets of MF patients who derive more (or less) clinical benefit from ruxolitinib therapy?

Myeloproliferative Neoplasms: Introduction and Background

What is acute leukemia?
Since MPNs have the potential to progress to acute myeloid leukemia (AML), are JAK kinase inhibitors being studied in post-MF AML?

Reasons People go off Ruxolitinib

Do the positive results of the Comfort-1 study regarding prolonged longevity and attentuation of symptoms provide rationale to be a universal treatment for myelofibrosis? Also, is panobinostat close to approval by a regulatory authority anywhere?

Treating Patients with Ruxolitinib who have Low Platelet Counts

In a patient with high risk ET- what platelet count is your trigger to initiate cytoreductive therapy? Once you start cytoreductive therapy what is the target platelet count that you are aiming to reach?


How common is it that two members of the same family to contract MPNs? is a member of the Oncology.TV family of oncology medical education websites. offers specialists, primary care physicians, and other healthcare professionals the timeliest comprehensive and relevant clinical information to improve patient care. We provide medical education (both free CE and non CE, including interactive case based presentations), news and information about Myeloproliferative Neoplasms (MPNs).